IL-21 May Promote Granzyme B-Dependent NK/Plasmacytoid Dendritic Cell Functional Interaction in Cutaneous Lupus Erythematosus
نویسندگان
چکیده
منابع مشابه
Cutaneous Manifestations of Systemic Lupus Erythematosus in Iranian Children
Systemic lupus erythematous (SLE) is an autoimmune process in which cutaneous lesions occur in majority of patients. This study was conducted to determine the pattern and prevalence of such lesions in SLE in Iranian children infected with SLE. Forty-eight patients, age between 3-16 yrs and male to female ratio of 7/1 were examined for the presence of cutaneous manifestations of SLE. The most co...
متن کاملIL-21-stimulated human plasmacytoid dendritic cells secrete granzyme B, which impairs their capacity to induce T-cell proliferation.
Plasmacytoid dendritic cells (pDCs) play a crucial role during innate immunity by secreting bulk amounts of type I interferons (IFNs) in response to Toll-like receptor (TLR)-mediated pathogen recognition. In addition, pDCs can also contribute to adaptive immunity by activation of antigen-specific T cells. Furthermore, it is well established that pDCs contribute to the pathogenesis of autoimmune...
متن کاملCytokines (IL-17, IL-23, and IL-33) in Systemic lupus erythematosus in Trinidad and Tobago.
Systemic lupus erythematosus (SLE) is the most common autoimmune disease. It is characterized by the presence of hundreds of autoantibodies against many organs and tissues, including the presence of a large number of autoantibodies, which are specific to self-antigens mainly of nuclear origin such as Smith antigen, double-stranded DNA (dsDNA), anti-Sjögren’s syndrome-related antigen A and B (SS...
متن کاملCutaneous lupus erythematosus
Keywords Definition/diagnostic criteria Etiology Clinical description Diagnostic criteria Diagnostic methods Differential diagnosis Epidemiology Management References Abstract Lupus erythematosus (LE) is a chronic, autoimmune, inflammatory disease that presents a striking diversity of clinical patterns with variable evolution and prognosis. Skin involvement (i.e cutaneous lupus erythematosus (C...
متن کاملAcute Cutaneous Lupus Erythematosus
The typical clinical manifestations of ACLE are characterized by a localized erythema known as the “malar rash” or “butterfly rash” on the central portion of the face or by a generalized, more widespread form (Fabbri et al. 2003, Sontheimer and Provost 2003). Localized ACLE may only affect the skin transiently, and the lesions may last for only several days up to a few weeks. Therefore, at the ...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2017
ISSN: 0022-202X
DOI: 10.1016/j.jid.2017.03.016